Hey all you game show fans out there - how’d you like to play America’s most exciting new show “Who Wants to Be an Oncologist?” Long considered some of our most esoteric, if not peculiar doctors, oncologists are usually depicted mumbling incomprehensible phrases to puzzled patients, poring over greasy charts full of hieroglyphics and scary pictures, eating greasy sandwiches, or staring dreamily out the window while pretending to listen to someone’s wheezy exhaust pipes.
What excitement! What high drama! Given the fact that (thanks to reality television) more and more folks are getting a chance to do something totally detached from the reality of their actual lives, why not give ‘em a shot at treating an actual cancer patient?
The concept is very simple. As your dapper host I will present an actual case to you and you get to choose between two alternative courses of action - in other words, you get to make the same decisions oncologists make every day. What could be more simple? Are you ready to play?
Hit the theme music!
Our case today is that of a 57 year old man with a ten centimeter mass in his right lower lobe on chest x-ray. Chest CT reveals the mass, with no other abnormalities seen. He weighs 289 pounds, has hypertension and a history of chronic bronchitis, and is on disability due to a “bad back.” He has smoked between one and two packs of cigarettes a day for 40 years.
Do you: A. Operate and remove the mass? or B. Order more x-rays?
Answer: C. Get a biopsy for diagnosis! Don’t you want to know what this is first, especially whether or not it is small cell lung cancer versus non-small cell lung cancer? ORDER AVOCAT ET OEUFS A LA MOUSSE DE CRABE IN FLUENT FRENCH.
Biopsy shows squamous cell carcinoma, and all staging scans including CT and PET/CT reveal no evidence of spread.
Do you: A. Operate and remove the mass? or B. Start radiation therapy?
Answer: C. Perform a cervical mediastinoscopy! Just because a PET/CT scan shows no fluorodeoxyglucose uptake in the mediastinal lymph nodes doesn’t mean they aren’t infiltrated with lung cancer, and if they are positive an operation would have very little chance to improve the patient’s long term survival. PERFORM ONE DEATH-DEFYING KICK.
We’ll be right back after these important messages……Hmm, let’s move on. The mediastinal lymph nodes are normal on biopsy, but the patient’s pulmonary function studies (done by the thoracic surgeon, thereby saving you a bit of embarrassment since you forgot to order them) reveal he has severe emphysema, precluding any chance for surgical resection.
Do you: A. Begin chemotherapy? or B. Begin radiation therapy?
Answer: C. [You were expecting maybe A or B?] Begin concurrent chemotherapy and radiation therapy! Did you forget that most experts agree that, based on the results of several recent studies, giving simultaneous chemotherapy and radiation therapy produces superior results compared with doing one or the other, or even giving both treatments sequentially? Hmm, did you?? SWALLOW ONE JUICY EARTHWORM.
Your patient brings you a news article stating that the monoclonal antibody Avastin produces longer survival for lung cancer patients when given with chemotherapy. He requests that you treat him with this new targeted therapy agent.
Do you: A. Begin Avastin now? or B. Wait until he is completed with radiation and then begin it?
Answer: C. [I knew that, wiseguy.] Oops! The plucky newspaper reporter forgot to mention in that story that patients with squamous cell carcinoma shouldn’t receive Avastin because of the risk of fatal pulmonary hemoptysis! So sorry! Also, patients with brain metastases, or on Coumadin, or those with large centrally located lung masses should not take Avastin either. ACT LIKE AN AVERAGE SCHMO.
Well, that buzzer means we’re out of time. We’d like to thank our contestants for playing today and have a parting gift for each of them - a home version of our game, along with a beautiful framed photograph of that little thing that hangs down at the back of your throat. Thank you, and good night.